⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL4962431 | 0.97 | ALDH1A1 (1.00) | — | |
| Aminothiazole SCHEMBL7401 | 0.97 | — | — | |
| Aminothiazole SCHEMBL10428703 | 0.97 | — | — | |
| Aminothiazole SCHEMBL1136755 | 0.97 | — | — | |
| Aminothiazole SCHEMBL7473421 | 0.94 | — | — | |
| Aminothiazole SCHEMBL11884793 | 0.94 | — | — | |
| Aminothiazole SCHEMBL2350289 | 0.94 | — | — | |
| Aminothiazole SCHEMBL1641818 | 0.94 | — | — | |
| Aminothiazole SCHEMBL7469112 | 0.94 | — | — | |
| Aminothiazole SCHEMBL29012817 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115902054-A | Method for detecting six genotoxic impurities in nitazoxanide bulk drug by UPLC-MS/MS | 南京卡文迪许生物工程技术有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-115902054-A | Method for detecting six genotoxic impurities in nitazoxanide bulk drug by UPLC-MS/MS | 南京卡文迪许生物工程技术有限公司 | 2023-04-04 | — | — | CN | disclosed |
| EP-1256578-B1 | Thiazole derivatives and their use as cdk inhibitors | PFIZER PROD INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20040192746-A1 | Thiazole derivatives | PFIZER INC | 2004-09-30 | — | — | US | disclosed |
| US-6720427-B2 | USED TO TREAT ABNORMAL CELL GROWTH AND CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2004-04-13 | — | — | US | disclosed |
| US-20030078252-A1 | Thiazole derivatives | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
| EP-1256578-A1 | Thiazole derivatives and their use as cdk inhibitors | Pfizer Products Inc. (US) | 2002-11-13 | — | — | EP | disclosed |