Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Aminothiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminothiazole SCHEMBL8009479 | 0.97 | — | — | |
| Aminothiazole SCHEMBL7401 | 0.97 | — | — | |
| Aminothiazole SCHEMBL10428703 | 0.97 | — | — | |
| Aminothiazole SCHEMBL1136755 | 0.97 | — | — | |
| Aminothiazole SCHEMBL4962431 | 0.97 | ALDH1A1 (1.00) | — | |
| Aminothiazole SCHEMBL7473421 | 0.94 | — | — | |
| Aminothiazole SCHEMBL7469112 | 0.94 | — | — | |
| Aminothiazole SCHEMBL5781624 | 0.94 | — | — | |
| Aminothiazole SCHEMBL1641818 | 0.94 | — | — | |
| Aminothiazole SCHEMBL11884793 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119977906-A | A-site cation-regulated halide perovskite, and preparation method and application thereof | 西北大学 | 2025-05-13 | — | — | CN | claimed |
| CN-117750864-A | Self-spreadable perovskite precursor solution with layered structure, material and solar cell | 浙江大学 | 2024-03-22 | — | — | CN | claimed |
| CN-119977906-A | A-site cation-regulated halide perovskite, and preparation method and application thereof | 西北大学 | 2025-05-13 | — | — | CN | disclosed |
| CN-117750864-A | Self-spreadable perovskite precursor solution with layered structure, material and solar cell | 浙江大学 | 2024-03-22 | — | — | CN | disclosed |
| CN-110869360-B | Phenylacetamides as ROCK inhibitors | 百时美施贵宝公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116867779-A | KRAS inhibitors for cancer treatment | 泰励生物科技（上海）有限公司 | 2023-10-10 | — | — | CN | disclosed |
| CN-114920738-A | KRas inhibitors for cancer treatment | 泰励生物科技（上海）有限公司 | 2022-08-19 | — | — | CN | disclosed |
| US-11173146-B2 | Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-16 | — | — | US | disclosed |
| CN-106938989-B | N- (5- benzyls thiazol-2-yl) acetamide derivative and the preparation method and application thereof | 湖南大学 | 2018-09-07 | — | — | CN | disclosed |
| CN-106188030-B | N- (5- piperonyls thiazol-2-yl) chlorinated amide derivative | 长沙理工大学 | 2018-08-21 | — | — | CN | disclosed |
| CN-107098898-A | Azacyclo-amino thiazole methyl qualone derivative and preparation method and application | 湖南大学 | 2017-08-29 | — | — | CN | disclosed |
| CN-101421265-A | Thiazole compounds as protein kinase b (pkb) inhibitors | AMGEN INC (US) | 2009-04-29 | — | — | CN | disclosed |
| US-7514566-B2 | Thiazole compounds and methods of use | AMGEN, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070173506-A1 | Thiazole compounds and methods of use | AMGEN INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-4243407-A | 2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides | GULF OIL CORPORATION (US) | 1981-01-06 | — | — | US | disclosed |
| US-4232163-A | 2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides | GULF OIL CORPORATION (US) | 1980-11-04 | — | — | US | disclosed |
| US-4152329-A | 2-ACYLAMINOTHIAZOL-4-YLACETAMIDES AS POST-EMERGENT SELECTIVE HERBICIDES | GULF OIL CORPORATION (US) | 1979-05-01 | — | — | US | disclosed |
| US-4120690-A | 2-Acylaminothiazol-4-ylacetamides as post-emergent selective herbicides | GULF OIL CORPORATION (US) | 1978-10-17 | — | — | US | disclosed |