SCHEMBL49631

SCHEMBL49631

Cc1cc(C)c(Oc2nc(Cl)nc(OCCCl)n2)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.46
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CRHR1 P34998 3/20 0.32
KMT2A Q03164 1/20 0.32
RXRA P19793 2/20 0.31
RXRB P28702 2/20 0.31
RXRG P48443 2/20 0.31
PTGS2 P35354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4319042 0.87 HSP90AA1 (0.41) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL49241 0.87 HSP90AA1 (0.41) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL49211 0.86 HSP90AA1 (0.53) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL9188392 0.85 HSP90AA1 (0.44) HSP90AA1CRHR1KMT2A
SCHEMBL4307871 0.82 HSP90AA1 (0.53) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL259402 0.81 HSP90AA1 (0.39) HSP90AA1ALDH1A1KMT2A
SCHEMBL16206669 0.74 ACHE (0.46) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL14940566 0.72 HSP90AA1 (0.53) HSP90AA1KDM4EALDH1A1CRHR1KMT2A
SCHEMBL11133843 0.72 CYP1A2 (0.39) ALDH1A1KMT2APTGS2
SCHEMBL4319812 0.72 HSP90AA1 (0.32) HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5159075-A Compatibilizers for copolymerization; impact strength GENERAL ELECTRIC COMPANY (US) 1992-10-27 US claimed
EP-0461433-A2 Substituted chlorotriazines useful for reactive capping of polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1991-12-18 EP claimed
US-8133844-B2 Heat-sensitive transfer image-receiving sheet FUJIFILM CORPORATION (JP) 2012-03-13 US disclosed
US-8129311-B2 Heat-sensitive transfer image-receiving sheet FUJIFILM CORPORATION (JP) 2012-03-06 US disclosed
US-8124563-B2 Heat-sensitive transfer image-receiving sheet FUJIFILM CORPORATION (JP) 2012-02-28 US disclosed
US-7981837-B2 Heat-sensitive transfer image-receiving sheet FUJIFILM CORPORATION (JP) 2011-07-19 US disclosed
US-7968495-B2 Heat-sensitive transfer image-receiving sheet and producing method thereof FUJIFILM CORPORATION (JP) 2011-06-28 US disclosed
US-7968496-B2 Heat-sensitive transfer image-receiving sheet, image forming method using heat-sensitive transfer system and method of producing heat-sensitive transfer image receiving sheet FUJIFILM CORPORATION (JP) 2011-06-28 US disclosed
US-7932210-B2 Image-forming method using thermal transfer system FUJIFILM CORPORATION (JP) 2011-04-26 US disclosed
US-7906267-B2 mulilayer, support, latex receivers with different elastic modulus and heat insulating polymer containing hollow particles FUJIFILM CORPORATION (JP) 2011-03-15 US disclosed
US-7897001-B2 Heat-sensitive transfer image-receiving sheet, producing method thereof and image-forming method FUJIFILM CORPORATION (JP) 2011-03-01 US disclosed
US-5264496-A Aromatic hydroxy group polymer modified with chlorotriazines and using phase transfer catalyst and tertiary amine for reaction GENERAL ELECTRIC COMPANY (US) 1993-11-23 US disclosed
US-5210191-A Substituted triazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1993-05-11 US disclosed
EP-0522767-A2 Method for preparing reactive triazine-capped aromatic polymers GENERAL ELECTRIC COMPANY (US) 1993-01-13 EP disclosed
US-5159075-A Compatibilizers for copolymerization; impact strength GENERAL ELECTRIC COMPANY (US) 1992-10-27 US disclosed
US-5089567-A Impact strength GENERAL ELECTRIC COMPANY (US) 1992-02-18 US disclosed
EP-0462410-A2 Copolymer-containing compositions from substituted triazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1991-12-27 EP disclosed
EP-0461434-A2 Substituted triazine-capped polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1991-12-18 EP disclosed
EP-0461433-A2 Substituted chlorotriazines useful for reactive capping of polyphenylene ethers GENERAL ELECTRIC COMPANY (US) 1991-12-18 EP disclosed
US-5010144-A Copolymerized with polyesters, polyamides and polyolefns contining nulceophilic groups; impact strength GENERAL ELECTRIC COMPANY (US) 1991-04-23 US disclosed