Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 11/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496318 | 1.00 | KLK5 (0.54) | KLK5DRD2PRMT5WDR77POLB | |
| SCHEMBL12635649 | 0.94 | KLK5 (0.55) | KLK5DRD2PRMT5WDR77POLB | |
| SCHEMBL496108 | 0.93 | KLK5 (0.57) | KLK5PRMT5WDR77 | |
| SCHEMBL496107 | 0.93 | KLK5 (0.57) | KLK5PRMT5WDR77 | |
| SCHEMBL12635676 | 0.85 | KLK5 (0.50) | KLK5PRMT5WDR77 | |
| SCHEMBL12635456 | 0.85 | KLK5 (0.50) | KLK5PRMT5WDR77 | |
| SCHEMBL12635437 | 0.85 | KLK5 (0.50) | KLK5PRMT5WDR77 | |
| SCHEMBL495862 | 0.85 | KLK5 (0.60) | KLK5 | |
| SCHEMBL495864 | 0.85 | KLK5 (0.60) | KLK5 | |
| SCHEMBL12635445 | 0.85 | KLK5 (0.49) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910317-B1 | 1-AMINO LINKED COMPOUNDS | LILLY CO ELI (US) | 2013-07-03 | — | — | EP | disclosed |
| US-8106090-B2 | Antidiabetic agents; prevent of non-insulin dependent diabetes | ELI LILLY AND COMPANY (US) | 2012-01-31 | — | — | US | disclosed |
| US-20080207735-A1 | 1-Amino Linked Compounds | ELI LILLY AND COMPANY | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207735-A1 | 1-Amino Linked Compounds | DPP4, DPP3, DPP9 | KLK5 3927/4885DRD2 277/4885PRMT5 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.