Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.55 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496319 | 0.94 | KLK5 (0.54) | KLK5DRD2PRMT5WDR77POLB | |
| SCHEMBL496318 | 0.94 | KLK5 (0.54) | KLK5DRD2PRMT5WDR77POLB | |
| SCHEMBL496108 | 0.91 | KLK5 (0.57) | KLK5PRMT5WDR77PSEN1PSEN2 | |
| SCHEMBL496107 | 0.91 | KLK5 (0.57) | KLK5PRMT5WDR77PSEN1PSEN2 | |
| SCHEMBL495862 | 0.88 | KLK5 (0.60) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL495864 | 0.88 | KLK5 (0.60) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL495686 | 0.87 | KLK5 (0.59) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL495688 | 0.87 | KLK5 (0.59) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12635456 | 0.84 | KLK5 (0.50) | KLK5PRMT5WDR77PSEN1PSEN2 | |
| SCHEMBL12635676 | 0.84 | KLK5 (0.50) | KLK5PRMT5WDR77PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283346-B2 | Human immunodeficiency virus protease inhibitors | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY (US) | 2012-10-09 | — | — | US | disclosed |
| US-20110112068-A1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITORS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112068-A1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE INHIBITORS | SERPINB1, PREP, TMPRSS15 | KLK5 257/4885CARM1 4149/4885DRD2 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.