Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 7/20 | 0.70 |
| ▸ | THRA | P10827 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962620 | 0.88 | THRA (0.63) | THRBTHRAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL1642151 | 0.85 | THRB (0.95) | THRBTHRA | |
| SCHEMBL1642271 | 0.84 | THRB (0.97) | THRBTHRA | |
| SCHEMBL1640812 | 0.82 | THRB (1.00) | THRBTHRA | |
| SCHEMBL1641890 | 0.80 | THRB (0.93) | THRBTHRAEPHX2 | |
| SCHEMBL1640576 | 0.78 | THRB (0.84) | THRBTHRA | |
| SCHEMBL4965254 | 0.78 | THRB (0.84) | THRBTHRAEPHX2 | |
| SCHEMBL4968443 | 0.77 | THRB (0.85) | THRBTHRAEPHX2 | |
| SCHEMBL1640560 | 0.77 | THRB (0.85) | THRBTHRA | |
| SCHEMBL1640362 | 0.75 | THRB (0.79) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268404-B1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2008-01-02 | — | — | EP | disclosed |