Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.64 |
| ▸ | THRA | P10827 | 18/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25773018 | 0.88 | THRB (0.71) | THRBTHRAESR1ESR2 | |
| SCHEMBL328377 | 0.88 | THRB (0.67) | THRBTHRAESR1ESR2 | |
| SCHEMBL1457668 | 0.85 | THRB (0.67) | THRBTHRAESR1ESR2 | |
| SCHEMBL27702889 | 0.85 | THRB (0.64) | THRBTHRAESR1ESR2 | |
| SCHEMBL28769044 | 0.84 | THRB (0.67) | THRBTHRA | |
| SCHEMBL12824810 | 0.84 | THRB (0.67) | THRBTHRAESR1ESR2 | |
| SCHEMBL10064689 | 0.82 | THRB (0.69) | THRBTHRA | |
| SCHEMBL4196757 | 0.82 | THRB (0.61) | THRBTHRAESR1ESR2 | |
| Hydrochloric Acid SCHEMBL1458369 | 0.82 | THRB (0.65) | THRBTHRAESR1ESR2 | |
| SCHEMBL13557776 | 0.82 | THRB (0.60) | THRBTHRAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101189248-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-28 | — | — | CN | disclosed |
| CN-101180097-A | Novel phosphinic acid-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-14 | — | — | CN | disclosed |
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |