Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.47 |
| ▸ | THRB | P10828 | 12/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27666494 | 0.92 | THRA (0.48) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL282654 | 0.83 | THRA (0.50) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL12824842 | 0.78 | MEN1 (0.51) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL13381672 | 0.78 | THRA (0.44) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL25856594 | 0.78 | THRB (0.67) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL282342 | 0.78 | THRA (0.47) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL22071776 | 0.77 | THRB (0.62) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL281929 | 0.77 | THRA (0.63) | THRATHRBSLC7A5OPRK1MEN1 | |
| Vk-0214 SCHEMBL283442 | 0.76 | THRB (0.79) | THRATHRBSLC7A5OPRK1MEN1 | |
| SCHEMBL29373597 | 0.76 | THRB (0.69) | THRATHRBSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |