Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.61 |
| ▸ | THRA | P10827 | 18/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457899 | 0.82 | THRB (0.68) | THRBTHRAESR1ESR2 | |
| SCHEMBL328377 | 0.82 | THRB (0.67) | THRBTHRAESR1ESR2 | |
| SCHEMBL13703189 | 0.82 | THRB (0.64) | THRBTHRAESR1ESR2 | |
| SCHEMBL4203861 | 0.82 | THRB (0.64) | THRBTHRAESR1ESR2 | |
| SCHEMBL27733429 | 0.82 | THRB (0.58) | THRBTHRAESR1ESR2 | |
| SCHEMBL13381780 | 0.81 | THRB (0.67) | THRBTHRAESR1ESR2 | |
| SCHEMBL1457900 | 0.81 | THRB (0.70) | THRBTHRA | |
| SCHEMBL27723475 | 0.81 | THRB (0.59) | THRBTHRAESR1ESR2 | |
| SCHEMBL3157044 | 0.81 | THRB (0.69) | THRBTHRA | |
| SCHEMBL3155783 | 0.80 | THRB (0.68) | THRBTHRAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |