Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031864 | 0.90 | ALDH1A1 (0.47) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL5100823 | 0.86 | TP53 (0.50) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL5094343 | 0.84 | MAPT (0.56) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL5100835 | 0.83 | MAPT (0.47) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL2472568 | 0.81 | TP53 (0.49) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL2473901 | 0.79 | TP53 (0.47) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL2473905 | 0.79 | TP53 (0.47) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL14208442 | 0.79 | MAPT (0.57) | MAPTTP53ALDH1A1PPARASMN1; SMN2 | |
| SCHEMBL6032070 | 0.77 | TP53 (0.48) | MAPTTP53ALDH1A1EPHX2NR1H4 | |
| SCHEMBL2468727 | 0.77 | TP53 (0.50) | MAPTTP53ALDH1A1EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904048-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007009959-A1 | GLEPP-1 INHIBITORS IN THE TREATMENT OF AUTOIMMUNE AND/OR INFLAMMATORY DISORDERS | LABORATOIRES SERONO S.A. (CH) | 2007-01-25 | — | — | WO | claimed |
| EP-1656139-A1 | ARYL DICARBOXAMIDES | Applied Research Systems ARS Holding N.V. (AN) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005011685-A1 | ARYL DICARBOXAMIDES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2005-02-10 | — | — | WO | disclosed |