Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.81 |
| ▸ | STK3 | Q13188 | 1/20 | 0.75 |
| ▸ | STK4 | Q13043 | 3/20 | 0.74 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20395134 | 0.92 | EGFR (0.69) | EGFRERBB2STK3STK4ERBB4 | |
| SCHEMBL2201863 | 0.92 | STK3 (0.82) | EGFRERBB2STK3STK4 | |
| SCHEMBL15320764 | 0.92 | EGFR (0.81) | EGFRERBB2 | |
| SCHEMBL20395133 | 0.91 | EGFR (0.83) | EGFRERBB2STK4ERBB4 | |
| SCHEMBL20395100 | 0.90 | EGFR (1.00) | EGFRERBB2ERBB4 | |
| SCHEMBL20412206 | 0.90 | EGFR (1.00) | EGFRERBB2STK3STK4ERBB4 | |
| SCHEMBL28547439 | 0.89 | EGFR (0.74) | EGFRERBB2STK3STK4 | |
| SCHEMBL20395683 | 0.89 | EGFR (0.84) | EGFRERBB2STK4ERBB4 | |
| SCHEMBL4963941 | 0.89 | EGFR (0.86) | EGFRERBB2 | |
| SCHEMBL4963947 | 0.89 | EGFR (0.86) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759583-B | Quinoline derivative containing furyl and preparation method and application thereof | 河南省医药科学研究院 | 2022-10-11 | — | — | CN | disclosed |
| CN-112694439-B | Phenyl acrylamide quinoline derivative and preparation method and application thereof | 河南省医药科学研究院 | 2022-08-30 | — | — | CN | disclosed |
| CN-112625025-B | Pyridyl substituted quinoline derivative and its prepn and use | 河南省医药科学研究院 | 2022-03-29 | — | — | CN | disclosed |
| CN-112759583-A | Quinoline derivative containing furyl and preparation method and application thereof | 河南省医药科学研究院 | 2021-05-07 | — | — | CN | disclosed |
| CN-112694439-A | Phenyl acrylamide quinoline derivative and preparation method and application thereof | 河南省医药科学研究院 | 2021-04-23 | — | — | CN | disclosed |
| CN-112625025-A | Pyridyl substituted quinoline derivative and its prepn and use | 河南省医药科学研究院 | 2021-04-09 | — | — | CN | disclosed |
| EP-1883631-A1 | METHODS OF SYNTHESIZING SUBSTITUTED 3-CYANOQUINOLINES AND INTERMEDIATES THEREOF | Wyeth (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006127207-A1 | METHODS OF SYNTHESIZING SUBSTITUTED 3-CYANOQUINOLINES AND INTERMEDIATES THEREOF | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060270668-A1 | Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof | WYETH (US) | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270668-A1 | Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof | HCCS, CYP3A7, QPCT | EGFR 4068/4885ERBB2 3200/4885STK3 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.