Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 9/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10471643 | 0.73 | MTNR1A (0.47) | ERN1ALDH1A1MAPTTSHR | |
| SCHEMBL1428875 | 0.72 | BCHE (0.57) | — | |
| SCHEMBL1429039 | 0.71 | AHR (0.49) | HTR6KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL14877078 | 0.71 | ALDH1A1 (0.58) | ERN1KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL15156299 | 0.70 | ALDH1A1 (0.49) | KDM4EALDH1A1CHKA | |
| SCHEMBL5506162 | 0.70 | ALDH1A1 (0.56) | ERN1KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL6413743 | 0.68 | TRIM24 (0.62) | ERN1KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL1740761 | 0.68 | ERN1 (0.49) | ERN1KDM4EL3MBTL1ALDH1A1MAPT | |
| SCHEMBL15475020 | 0.68 | ALDH1A1 (0.54) | KDM4EALDH1A1 | |
| SCHEMBL4698273 | 0.67 | ALDH1A1 (0.53) | ERN1KDM4EL3MBTL1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957478-A2 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007061360-A2 | NOVEL 3-BICYCLOCARBONYLAMINOPYRIDINE-2-CARBOXAMIDES OR 3-BICYCLOCARBONYLAMINOPYRAZINE-2-CARBOXAMIDES | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | WO | claimed |