Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.64 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | WDR5 | P61964 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505443 | 0.82 | HTR6 (0.74) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4966544 | 0.82 | HTR6 (0.74) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4509755 | 0.80 | HTR6 (0.71) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4515515 | 0.79 | HTR6 (0.73) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4522178 | 0.79 | HTR6 (0.64) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4505107 | 0.79 | HTR6 (0.64) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4961410 | 0.78 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4529672 | 0.78 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4521081 | 0.78 | HTR6 (1.00) | HTR6QRFPRALDH1A1TP53WDR5 | |
| SCHEMBL4513947 | 0.77 | HTR6 (0.67) | HTR6QRFPRALDH1A1TP53WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888518-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126938-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |