Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009737 | 0.86 | CHRNA7 (0.54) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL2733241 | 0.81 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL10858992 | 0.79 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL883731 | 0.75 | ATM (0.57) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL29403584 | 0.75 | ATM (0.57) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL16606311 | 0.75 | CYP1A2 (0.63) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 | |
| SCHEMBL8009741 | 0.74 | CHRNA7 (0.70) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3544868 | 0.74 | ATM (0.55) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL10282657 | 0.73 | TDP1 (0.58) | CHRNA7CHRNB2CHRNA4TDP1L3MBTL1 | |
| SCHEMBL22762044 | 0.72 | CYP1A2 (0.51) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016643-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | claimed |
| WO-2008016643-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |