Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | IDE | P14735 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966895 | 0.84 | PIK3CA (0.41) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL5143901 | 0.77 | PIK3CA (0.41) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3043425 | 0.77 | PIK3CA (0.40) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL402842 | 0.72 | PIK3CA (0.40) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4966033 | 0.69 | LMNA (0.33) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL5070139 | 0.68 | ALDH1A1 (0.35) | KDM4EHTTALDH1A1LMNAPOLB | |
| SCHEMBL400515 | 0.67 | NPSR1 (0.41) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL3736977 | 0.67 | PIK3CA (0.46) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL15450881 | 0.64 | PIK3R1 (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL5140882 | 0.63 | ALDH1A1 (0.41) | KDM4EALOX15HTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959962-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2007078815-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-07-12 | — | — | WO | claimed |