Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | DBH | P09172 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850869 | 0.77 | HTR6 (0.54) | HTR6SLC2A1MAPK14ALDH1A1LMNA | |
| SCHEMBL3851817 | 0.76 | HTR6 (0.48) | HTR6SLC2A1MAPK14DRD2MPO | |
| SCHEMBL18069184 | 0.74 | HTR6 (0.69) | HTR6DRD2 | |
| SCHEMBL8685326 | 0.74 | ALDH1A1 (0.72) | HTR6SLC2A1ALDH1A1LMNATDP1 | |
| SCHEMBL18049242 | 0.72 | HTR6 (0.67) | HTR6MAPK14ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL31258087 | 0.72 | HTR6 (0.55) | HTR6SLC2A1ALDH1A1LMNATDP1 | |
| SCHEMBL1104768 | 0.72 | HTR6 (0.55) | HTR6SLC2A1ALDH1A1LMNATDP1 | |
| SCHEMBL12543405 | 0.71 | HTR2C (0.46) | HTR6NPSR1 | |
| SCHEMBL18045050 | 0.71 | HTR6 (0.43) | HTR6LMNAL3MBTL1 | |
| Ethoxycarbonyl Group SCHEMBL28763762 | 0.71 | EPHX2 (0.47) | SLC2A1ALDH1A1LMNATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |