Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.46 |
| ▸ | FEN1 | P39748 | 5/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9574598 | 0.98 | ALOX5AP (0.47) | ALOX5APFEN1LRRK2JAK3FFAR4 | |
| SCHEMBL20240553 | 0.96 | ALOX5AP (0.46) | ALOX5APFEN1LRRK2JAK3FFAR4 | |
| SCHEMBL31702258 | 0.93 | ALOX5AP (0.43) | ALOX5APFEN1GRM4 | |
| SCHEMBL20687907 | 0.93 | ALOX5AP (0.43) | ALOX5APFEN1GRM4 | |
| SCHEMBL2369803 | 0.85 | GRM4 (0.40) | ALOX5APFEN1GRM4 | |
| Hydrochloric Acid SCHEMBL4714047 | 0.85 | FEN1 (0.50) | ALOX5APFEN1GRM4 | |
| SCHEMBL29445482 | 0.85 | GRM4 (0.53) | ALOX5APFEN1LRRK2GRM4 | |
| SCHEMBL20689383 | 0.85 | ALOX5AP (0.42) | ALOX5APFEN1LRRK2GRM4 | |
| SCHEMBL1936639 | 0.85 | GRM4 (0.53) | ALOX5APFEN1LRRK2GRM4 | |
| Hydrochloric Acid SCHEMBL4714045 | 0.85 | FEN1 (0.50) | ALOX5APFEN1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899319-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006135649-A2 | AMINOQUINOLINE AND AMINOQUINAZOLINE KINASE MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | WO | disclosed |