Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.40 |
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967803 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CMAPK8 | |
| SCHEMBL4969181 | 1.00 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CMAPK8 | |
| SCHEMBL14116479 | 0.91 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CSLC5A2 | |
| SCHEMBL4966888 | 0.91 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CSLC5A2 | |
| SCHEMBL4966904 | 0.91 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CSLC5A2 | |
| SCHEMBL4968269 | 0.88 | RORC (0.38) | ACACB | |
| SCHEMBL4968239 | 0.87 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMAPK8 | |
| SCHEMBL4966002 | 0.87 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMAPK8 | |
| SCHEMBL4966013 | 0.87 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMAPK8 | |
| SCHEMBL4968649 | 0.81 | PDE4D (0.38) | PDE4DPDE4APDE4BPDE4CSLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101938-A1 | GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZONITRILE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-28 | — | — | WO | disclosed |
| WO-2008101938-A1 | GLUCOPYRANOSYL-SUBSTITUTED BENZYL-BENZONITRILE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-28 | — | — | WO | disclosed |