Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 10/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186273 | 0.80 | SMN1; SMN2 (0.49) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL12233588 | 0.79 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL15223500 | 0.78 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL15971808 | 0.77 | PRKDC (0.46) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL3439414 | 0.75 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL29417566 | 0.75 | SMN1; SMN2 (0.52) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL11918962 | 0.75 | SMN1; SMN2 (0.49) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL28296111 | 0.73 | ALDH1A1 (0.52) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL12257113 | 0.72 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL28045432 | 0.71 | SMN1; SMN2 (0.48) | RAB9ANPC1SMN1; SMN2LRRK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006091671-A1 | IMIDAZO (1, 2-A) PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-08-31 | — | — | WO | disclosed |