SCHEMBL4968167

SCHEMBL4968167

Cc1cc(OCCCN2CCOCC2)ccc1S(=O)(=O)Nc1nc(CC2(O)CCCCC2)cs1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 2/20 0.41
HRH3 Q9Y5N1 6/20 0.39
EPHX2 P34913 3/20 0.39
UBE2N P61088 1/20 0.39
TRPV4 Q9HBA0 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
HDAC9 Q9UKV0 1/20 0.38
HDAC5 Q9UQL6 1/20 0.38
MCL1 Q07820 1/20 0.38
NPC1 O15118 1/20 0.37
ALDH1A1 P00352 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4963884 0.93 ROCK1 (0.40) ROCK1HRH3EPHX2UBE2NTRPV4
SCHEMBL4964132 0.83 ROCK1 (0.42) ROCK1HRH3EPHX2UBE2NTRPV4
SCHEMBL4963643 0.83 ROCK1 (0.42) ROCK1HRH3EPHX2UBE2NTRPV4
SCHEMBL4964526 0.80 HRH3 (0.43) ROCK1HRH3EPHX2UBE2NSIGMAR1
SCHEMBL4965583 0.79 NPC1 (0.43) ROCK1UBE2NTRPV4NPC1ALDH1A1
SCHEMBL4964680 0.79 MEN1 (0.43) ROCK1UBE2NTRPV4NPC1ALDH1A1
SCHEMBL4962659 0.79 HRH3 (0.42) ROCK1HRH3EPHX2UBE2NSIGMAR1
SCHEMBL4966824 0.78 NPC1 (0.42) ROCK1UBE2NTRPV4NPC1ALDH1A1
SCHEMBL4969260 0.77 ROCK1 (0.42) ROCK1HRH3EPHX2UBE2NTRPV4
SCHEMBL4966984 0.71 HDAC3 (0.48) ROCK1HRH3EPHX2HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1888544-A2 HYDROXYSTEROID DEHYDROGENASE INHIBITORS Takeda San Diego, Inc. (US) 2008-02-20 EP claimed
WO-2006066109-A2 HYDROXYSTEROID DEHYDROGENASE INHIBITORS TAKEDA SAN DIEGO, INC. (US) 2006-06-22 WO claimed