Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964132 | 0.96 | ROCK1 (0.42) | NPC1SMN1; SMN2ALDH1A1ROCK1UBE2N | |
| SCHEMBL4966824 | 0.92 | NPC1 (0.42) | NPC1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4964680 | 0.86 | MEN1 (0.43) | NPC1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4963210 | 0.85 | TRPV4 (0.40) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4966468 | 0.84 | TRPV4 (0.39) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4966984 | 0.84 | HDAC3 (0.48) | SMN1; SMN2ALDH1A1ROCK1CA12CA1 | |
| SCHEMBL4970500 | 0.83 | HSD11B1 (0.44) | NPC1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL4964824 | 0.83 | EPHX2 (0.49) | SMN1; SMN2KDM4EALDH1A1ROCK1TRPV4 | |
| SCHEMBL4966262 | 0.83 | KMT2A (0.40) | MEN1KMT2AKDM4EALDH1A1HSD11B1 | |
| SCHEMBL4963643 | 0.82 | ROCK1 (0.42) | NPC1MEN1KMT2AALDH1A1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |