Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294232 | 0.88 | NPSR1 (0.37) | PPARGLDHALDHBFFAR1PPARD | |
| SCHEMBL27739631 | 0.79 | PPARA (0.39) | PPARGPPARAPPARD | |
| SCHEMBL2545468 | 0.79 | PDPK1 (0.37) | PDPK1AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL1742721 | 0.79 | PDPK1 (0.37) | PDPK1AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL4977115 | 0.78 | CES2 (0.43) | PDPK1AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL5165429 | 0.78 | AKR1C3 (0.43) | PDPK1AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL4292305 | 0.77 | PPARG (0.41) | AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL12056590 | 0.77 | PPARG (0.40) | PPARGPPARAFFAR1PSENEN | |
| SCHEMBL1147460 | 0.77 | PDPK1 (0.41) | PDPK1AKR1C3AKR1C2PPARGPPARA | |
| SCHEMBL1594262 | 0.76 | LDHA (0.39) | AKR1C3AKR1C2PPARGPPARALDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |