Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.35 |
| ▸ | MTOR | P42345 | 4/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL633585 | 0.84 | PIK3CA (0.39) | PIK3CAMTORAKT1ATMATR | |
| SCHEMBL4251746 | 0.79 | PIK3CA (0.36) | PIK3CAMTORAKT1ATMATR | |
| SCHEMBL1448068 | 0.73 | CYP11B2 (0.34) | PIK3CAMTOR | |
| SCHEMBL4245167 | 0.72 | MAPK14 (0.43) | PIK3CAMTORMAPK14PIK3R1FEN1 | |
| SCHEMBL4246503 | 0.72 | ALDH1A1 (0.38) | PIK3CAMTORMAPK14JAK2JAK1 | |
| SCHEMBL14092794 | 0.72 | CDK2 (0.39) | PIK3CAMTORAKT1MAPK14MAPK8 | |
| Hydrochloric Acid SCHEMBL4964435 | 0.71 | JAK2 (0.41) | MAPK14MAPK8JAK2JAK1JAK3 | |
| SCHEMBL4462397 | 0.70 | CDK1 (0.55) | MAPK14MAPK8 | |
| SCHEMBL4249428 | 0.70 | CDK2 (0.39) | PIK3CAMAPK14PIK3CBJAK2JAK1 | |
| SCHEMBL4426967 | 0.70 | CDK2 (0.38) | PIK3CAMTORAKT1MAPK14MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945628-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007040440-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |