Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.56 |
| ▸ | CLK1 | P49759 | 3/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.56 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 4/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.55 |
| ▸ | CLK3 | P49761 | 1/20 | 0.55 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496844 | 1.00 | CRHBP (0.56) | CRHBPCRHR2DYRK1ADYRK2CLK4 | |
| SCHEMBL10093409 | 1.00 | CRHBP (0.56) | CRHBPCRHR2DYRK1ADYRK2CLK4 | |
| SCHEMBL2882375 | 0.90 | CISD1 (0.60) | DYRK1ADYRK2PIK3CDCSNK2A2PIK3CA | |
| SCHEMBL12975463 | 0.90 | CISD1 (0.60) | DYRK1ADYRK2PIK3CDCSNK2A2PIK3CA | |
| SCHEMBL2882373 | 0.90 | CISD1 (0.60) | DYRK1ADYRK2PIK3CDCSNK2A2PIK3CA | |
| SCHEMBL2882012 | 0.87 | PIP4K2A (0.48) | CRHBPCRHR2DYRK1ADYRK2CLK4 | |
| SCHEMBL12975484 | 0.87 | PIP4K2A (0.48) | CRHBPCRHR2DYRK1ADYRK2CLK4 | |
| SCHEMBL2882014 | 0.87 | PIP4K2A (0.48) | CRHBPCRHR2DYRK1ADYRK2CLK4 | |
| SCHEMBL10093421 | 0.85 | DYRK3 (0.46) | DYRK1ADYRK2CLK4PIK3CDCSNK2A2 | |
| SCHEMBL496986 | 0.85 | DYRK3 (0.46) | DYRK1ADYRK2CLK4PIK3CDCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| EP-1648452-B1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | MERCK SERONO SA (CH) | 2009-07-22 | — | — | EP | disclosed |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | PI4K2B, PI4KA, PTK2B | CRHBP 4009/4885CRHR2 4160/4885DYRK1A 2093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.