Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Naphazoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.74 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.74 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.74 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.74 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.74 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | HTR1A | P08908 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphazoline SCHEMBL16241749 | 0.90 | TAAR1 (0.82) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL29369882 | 0.86 | TAAR1 (1.00) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL34532 | 0.86 | TAAR1 (1.00) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL28545257 | 0.85 | TAAR1 (0.78) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL12481545 | 0.85 | TAAR1 (0.97) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL26087856 | 0.85 | TAAR1 (0.97) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL1649580 | 0.85 | TAAR1 (0.97) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL24153 | 0.85 | TAAR1 (1.00) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL29389962 | 0.85 | TAAR1 (1.00) | TAAR1NISCHCYP2D6LMNAADRA2A | |
| Naphazoline SCHEMBL7039049 | 0.84 | TAAR1 (0.84) | TAAR1NISCHCYP2D6LMNAADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804761-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | EVERA LAB LLC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-1804761-A4 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | EVERA LAB LLC (US) | 2008-09-17 | — | — | EP | disclosed |
| US-7288263-B2 | Compositions and methods for treatment of skin discoloration | EVERA LABORATORIES, LLC (US) | 2007-10-30 | — | — | US | disclosed |
| EP-1804761-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | Boxrud, Cynthia A. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006031555-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF SKIN DISCOLORATION | BOXRUD, CYNTHIA, A. (US) | 2006-03-23 | — | — | WO | disclosed |
| US-20060057081-A1 | Compositions and methods for treatment of skin discoloration | EVERA LABORATORIES, LLC | 2006-03-16 | — | — | US | disclosed |