Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432856 | 0.72 | MAPT (0.72) | CYP3A4ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL21067939 | 0.70 | CLK1 (0.50) | CYP3A4MAPTKMT2AKDM4EDYRK2 | |
| SCHEMBL6523611 | 0.70 | PIM1 (0.39) | ALDH1A1MAPTKMT2ATDP1HSD17B10 | |
| SCHEMBL1987675 | 0.69 | CYP3A4 (0.71) | CYP3A4ATMALDH1A1MAPTKMT2A | |
| SCHEMBL19500874 | 0.68 | CYP19A1 (0.78) | CYP3A4ATMALDH1A1MAPTKDM4E | |
| SCHEMBL8580709 | 0.68 | ALDH1A1 (0.69) | CYP3A4ATMALDH1A1MAPTKMT2A | |
| SCHEMBL19472000 | 0.68 | CYP19A1 (0.78) | CYP3A4ATMALDH1A1MAPTKDM4E | |
| SCHEMBL22275227 | 0.67 | ALDH1A1 (0.59) | CYP3A4ATMALDH1A1MAPTKMT2A | |
| SCHEMBL10602395 | 0.67 | KMT2A (0.58) | ALDH1A1MAPTKMT2AKDM4ETDP1 | |
| SCHEMBL2882197 | 0.67 | GSK3B (0.83) | ALDH1A1MAPTKMT2AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | PI4K2B, PI4KA, PTK2B | CYP3A4 1956/4885ATM 260/4885ALDH1A1 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.