Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974420 | 0.77 | ALDH1A1 (0.69) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL6112913 | 0.74 | ALDH1A1 (0.69) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL27048502 | 0.72 | ALDH1A1 (0.54) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL13036621 | 0.72 | ALDH1A1 (0.54) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL5750125 | 0.72 | KDM4E (0.50) | ALDH1A1GAAPOLBKMT2AMEN1 | |
| SCHEMBL9924041 | 0.71 | ALDH1A1 (0.50) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL6112856 | 0.70 | ALDH1A1 (0.67) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL18894160 | 0.69 | ALDH1A1 (0.51) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL15266482 | 0.69 | ALDH1A1 (0.51) | ALDH1A1GAAPOLBCYP1A2CYP2C9 | |
| SCHEMBL19723541 | 0.69 | CYP1A2 (0.61) | ALDH1A1GAAPOLBCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |