Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746203 | 0.83 | NPC1 (0.50) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28007924 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1768162 | 0.76 | SMN1; SMN2 (0.61) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6112657 | 0.73 | KMT2A (0.64) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2929154 | 0.72 | GAA (0.58) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19723534 | 0.72 | GAA (0.58) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4968771 | 0.72 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12832208 | 0.71 | ALDH1A1 (0.59) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1768201 | 0.71 | RAB9A (0.69) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7235017 | 0.71 | NPC1 (0.49) | KDM4EALDH1A1MAPTSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549650-B1 | SUBSTITUTED C-IMIDAZO[1,2-A]PYRIDIN-3-YL-METHYLAMINES | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |
| EP-1549650-A1 | SUBSTITUTED C-IMIDAZO[1,2-A]PYRIDIN-3-YL-METHYLAMINES | Grünenthal GmbH (DE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033453-A1 | SUBSTITUTED C-IMIDAZO[1,2-A]PYRIDIN-3-YL-METHYLAMINES | Grünenthal GmbH (DE) | 2004-04-22 | — | — | WO | disclosed |