Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220893 | 0.87 | MAPT (0.74) | SMN1; SMN2KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4890267 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL2788439 | 0.84 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL6878797 | 0.84 | ALDH1A1 (0.62) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL6877987 | 0.84 | GAA (0.59) | SMN1; SMN2KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL4294435 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL7419507 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL9329409 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL13352089 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL3933173 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2KMT2AALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |
| EP-1587800-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | Astellas Pharma Inc. (JP) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004067521-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-08-12 | — | — | WO | disclosed |
| WO-1993004070-A1 | SUBSTITUTED ACRYLAMIDO-PENICILLANIC ACID DERIVATIVES | SMITHKLINE BEECHAM, PLC (GB) | 1993-03-04 | — | — | WO | disclosed |
| EP-0421752-A2 | Substituted acrylamido-penicillanic acid derivatives | Beecham Group p.l.c. (GB) | 1991-04-10 | — | — | EP | disclosed |
| US-4954489-A | ACYLATION | BEECHAM GROUP P.L.C. (GB) | 1990-09-04 | — | — | US | disclosed |
| EP-0337643-A2 | 6-Substituted acrylamido penicillanic acid derivatives, preparation and use | BEECHAM GROUP PLC (GB) | 1989-10-18 | — | — | EP | disclosed |