Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 9/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 9/20 | 0.63 |
| ▸ | KCNE1 | P15382 | 7/20 | 0.63 |
| ▸ | KCNQ1 | P51787 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969552 | 0.91 | MAPT (0.60) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL403003 | 0.91 | KCNQ3 (0.68) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL4972665 | 0.90 | KCNQ3 (0.66) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL4967489 | 0.84 | KMT2A (0.63) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL1986996 | 0.84 | KCNQ3 (0.82) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL3134896 | 0.83 | KCNQ3 (0.78) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL403184 | 0.82 | KCNQ3 (0.67) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL402589 | 0.82 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL404209 | 0.81 | SMN1; SMN2 (0.74) | KCNQ3KCNQ2KCNE1KCNQ1MAPT | |
| SCHEMBL401818 | 0.81 | KCNQ3 (0.71) | KCNQ3KCNQ2KCNE1KCNQ1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |