Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 9/20 | 0.82 |
| ▸ | KCNQ2 | O43526 | 9/20 | 0.82 |
| ▸ | KCNE1 | P15382 | 7/20 | 0.82 |
| ▸ | KCNQ1 | P51787 | 7/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217440 | 0.90 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL5215207 | 0.90 | KCNQ3 (0.81) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL3313800 | 0.89 | RAB9A (0.75) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL11555293 | 0.88 | KCNQ3 (0.64) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2801974 | 0.87 | KCNQ3 (0.85) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL8361559 | 0.87 | RAB9A (1.00) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2306301 | 0.87 | RAB9A (0.76) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL403003 | 0.85 | KCNQ3 (0.68) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL1844238 | 0.84 | RAB9A (0.74) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A | |
| SCHEMBL2302748 | 0.84 | RAB9A (0.74) | KCNQ3KCNQ2KCNE1KCNQ1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222275-B2 | Biarylcarboxyarylamides as vanilloid-1 receptor modulators | PHARMESTE S.R.L. (IT) | 2012-07-17 | — | — | US | disclosed |
| CN-101490006-B | Biaryl carboxylic acid arylamides as vanilloid-1 receptor modulators | PHARMESTE SRL | 2012-05-23 | — | — | CN | disclosed |
| EP-2041094-B1 | BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS | PHARMESTE SRL (IT) | 2011-06-29 | — | — | EP | disclosed |
| US-20100081687-A1 | BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS | PHARMESTE S.R.L. (IT) | 2010-04-01 | — | — | US | disclosed |
| CN-101490006-A | Biaryl carboxylic acid arylamides as vanilloid-1 receptor modulators | PHARMESTE SRL (IT) | 2009-07-22 | — | — | CN | disclosed |
| EP-2048133-A1 | Nicotinamide n-oxide derivatives as vanilloid-1 receptor modulators | Pharmeste S.r.l. (IT) | 2009-04-15 | — | — | EP | disclosed |
| WO-2009043582-A1 | NICOTINAMIDE N-OXIDE DERIVATIVES AS VANILLOID-1 RECEPTOR MODULATORS | PHARMESTE S.R.L. (IT) | 2009-04-09 | — | — | WO | disclosed |
| EP-2041094-A1 | BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS | Pharmeste S.r.l. (IT) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006480-A1 | BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS | PHARMESTE S.R.L. (IT) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081687-A1 | BIARYLCARBOXYARYLAMIDES AS VANILLOID-1 RECEPTOR MODULATORS | TRPV1, TRPV3, TRPV2 | KCNQ3 400/4885KCNQ2 398/4885KCNE1 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.