Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426983 | 0.84 | KDR (0.53) | BRAFRXFP1MCHR1EPHX2KDR | |
| SCHEMBL5420350 | 0.83 | KDR (0.52) | BRAFMCHR1KDRHTR2AHTR2C | |
| SCHEMBL4969245 | 0.83 | MCHR1 (0.70) | MCHR1KDRMEN1NPC1POLB | |
| SCHEMBL546280 | 0.82 | KDR (0.53) | BRAFKDRHTR2AHTR2CLTA4H | |
| SCHEMBL546211 | 0.82 | KDR (0.68) | BRAFKDRHTR2AHTR2C | |
| SCHEMBL27289490 | 0.82 | MET (0.49) | BRAFRXFP1MCHR1EPHX2KDR | |
| SCHEMBL5438836 | 0.81 | KDR (0.54) | BRAFKDR | |
| SCHEMBL10199786 | 0.80 | KDR (0.51) | BRAFRXFP1MCHR1EPHX2KDR | |
| SCHEMBL27289467 | 0.78 | BRAF (0.47) | BRAFRXFP1MCHR1EPHX2KDR | |
| SCHEMBL546100 | 0.78 | KDR (0.49) | BRAFRXFP1MCHR1KDRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110687-B2 | Bicyclic compounds with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-07 | — | — | US | disclosed |