Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552272 | 1.00 | PRCP (0.49) | PRCPHTR1ASIGMAR1ANPEPALDH1A1 | |
| SCHEMBL4121058 | 0.81 | PRCP (0.46) | PRCPHTR1AANPEPALDH1A1HTR2A | |
| SCHEMBL4116682 | 0.81 | PRCP (0.46) | PRCPHTR1AANPEPALDH1A1HTR2A | |
| SCHEMBL4120258 | 0.81 | PRCP (0.46) | PRCPHTR1AANPEPALDH1A1HTR2A | |
| SCHEMBL4128510 | 0.79 | SIGMAR1 (0.48) | SIGMAR1ANPEP | |
| SCHEMBL4117548 | 0.79 | SIGMAR1 (0.48) | SIGMAR1ANPEP | |
| SCHEMBL4117310 | 0.79 | SIGMAR1 (0.48) | SIGMAR1ANPEP | |
| SCHEMBL4126331 | 0.73 | XIAP (0.54) | PRCPHTR1AANPEPHTR2AADRA2A | |
| SCHEMBL4122465 | 0.73 | XIAP (0.54) | PRCPHTR1AANPEPHTR2AADRA2A | |
| SCHEMBL4122057 | 0.73 | XIAP (0.54) | PRCPHTR1AANPEPHTR2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345955-B1 | LACTAM DIPEPTIDE AND ITS USE IN INHIBITING BETA-AMYLOID PEPTIDE RELEASE | LILLY CO ELI (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1353910-B1 | LACTAM COMPOUND | LILLY CO ELI (US) | 2007-05-23 | — | — | EP | disclosed |