Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.31 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967775 | 0.89 | USP30 (0.36) | USP30TRPA1FFAR2S1PR3AAK1 | |
| SCHEMBL4968016 | 0.83 | USP30 (0.36) | USP30TRPM8CPB2FFAR2PDE2A | |
| SCHEMBL4970661 | 0.82 | PPARG (0.32) | PPARGPPARATRPA1AAK1PDE2A | |
| SCHEMBL2544470 | 0.78 | PPARG (0.35) | TRPM8PPARGPPARACPB2FFAR2 | |
| SCHEMBL2546509 | 0.77 | PPARG (0.35) | TRPM8PPARGPPARACPB2P2RY2 | |
| SCHEMBL1744190 | 0.76 | PPARG (0.32) | TRPM8PPARGPPARACPB2 | |
| SCHEMBL4303579 | 0.75 | PPARG (0.39) | PPARGPPARAFFAR2AAK1 | |
| SCHEMBL4303581 | 0.75 | PPARG (0.39) | PPARGPPARAFFAR2AAK1 | |
| SCHEMBL1742112 | 0.75 | PPARG (0.39) | TRPM8PPARGPPARATRPA1S1PR3 | |
| SCHEMBL2544478 | 0.74 | PPARG (0.36) | TRPM8PPARGPPARAFFAR2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |