Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969320 | 0.83 | USP30 (0.38) | USP30TRPM8FFAR2CPB2PDE2A | |
| SCHEMBL4294361 | 0.81 | TRPM8 (0.34) | TRPM8CPB2PTGER4PTGER2PDE2A | |
| SCHEMBL4294354 | 0.81 | TRPM8 (0.34) | TRPM8CPB2PTGER4PTGER2PDE2A | |
| SCHEMBL4294345 | 0.75 | RORC (0.33) | TRPM8CPB2PTGER4PTGER2PDE2A | |
| SCHEMBL4294350 | 0.75 | RORC (0.33) | TRPM8CPB2PTGER4PTGER2PDE2A | |
| SCHEMBL4294129 | 0.74 | TRPM8 (0.32) | TRPM8CPB2 | |
| SCHEMBL4294135 | 0.74 | TRPM8 (0.32) | TRPM8CPB2 | |
| SCHEMBL4967775 | 0.73 | USP30 (0.36) | USP30FFAR2 | |
| SCHEMBL2544470 | 0.72 | PPARG (0.35) | TRPM8FFAR2CPB2 | |
| SCHEMBL123047 | 0.72 | USP30 (0.60) | USP30FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |