Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 10/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 10/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969320 | 0.89 | USP30 (0.38) | USP30TRPA1FFAR2S1PR3AAK1 | |
| SCHEMBL2551213 | 0.75 | CA1 (0.37) | P2RX3P2RX2NR1I2CYP2C9CA1 | |
| SCHEMBL1741864 | 0.74 | GPR139 (0.40) | P2RX3P2RX2NR1I2CYP2C9CA1 | |
| SCHEMBL2550148 | 0.74 | ATM (0.35) | CYP2C9CA1CA2CA4CA7 | |
| SCHEMBL4298661 | 0.74 | ATM (0.35) | CYP2C9CA1CA2CA4CA7 | |
| SCHEMBL2550153 | 0.74 | ATM (0.35) | CYP2C9CA1CA2CA4CA7 | |
| SCHEMBL30277283 | 0.73 | CYP2C9 (0.48) | P2RX3P2RX2NR1I2CYP2C9TRPA1 | |
| SCHEMBL19962270 | 0.73 | CYP2C9 (0.48) | P2RX3P2RX2NR1I2CYP2C9TRPA1 | |
| SCHEMBL4968016 | 0.73 | USP30 (0.36) | USP30FFAR2 | |
| SCHEMBL123047 | 0.73 | USP30 (0.60) | USP30FFAR2AAK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | Amgen, Inc (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084391-A2 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B ( PKB) INHIBITORS | AMGEN INC. (US) | 2007-07-26 | — | — | WO | disclosed |