Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609953 | 0.88 | MEN1 (0.44) | RENKMT2APGRCYP2D6CYP2C9 | |
| SCHEMBL3609955 | 0.88 | MEN1 (0.44) | RENKMT2APGRCYP2D6CYP2C9 | |
| SCHEMBL3609954 | 0.88 | MEN1 (0.44) | RENKMT2APGRCYP2D6CYP2C9 | |
| SCHEMBL4970765 | 0.82 | USP30 (0.35) | RENUSP30 | |
| SCHEMBL4972459 | 0.81 | REN (0.59) | REN | |
| SCHEMBL4972466 | 0.81 | REN (0.59) | REN | |
| SCHEMBL4973229 | 0.80 | REN (0.39) | RENALDH1A1 | |
| SCHEMBL2329294 | 0.78 | REN (0.47) | REN | |
| SCHEMBL2329296 | 0.78 | REN (0.47) | REN | |
| SCHEMBL2328270 | 0.78 | REN (0.47) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966139-A1 | ASPARTIC PROTEASE INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070201-A1 | ASPARTIC PROTEASE INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |