Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3540093 | 0.89 | CNR1 (0.45) | CNR1CNR2HTR2CNPC1RAB9A | |
| SCHEMBL4973394 | 0.85 | CNR1 (0.41) | CNR1CNR2HTR2CACKR3TRPC3 | |
| SCHEMBL4970419 | 0.84 | HTR2C (0.46) | HTR2CNPC1RAB9ATRPC3TRPC6 | |
| SCHEMBL4972781 | 0.84 | HTR2C (0.38) | CNR1CNR2HTR2CACKR3TRPC3 | |
| SCHEMBL4973873 | 0.84 | RAB9A (0.43) | CNR1CNR2HTR2CNPC1RAB9A | |
| SCHEMBL4973946 | 0.83 | ACKR3 (0.40) | CNR1CNR2HTR2CACKR3SCD5 | |
| SCHEMBL4975252 | 0.83 | ACKR3 (0.40) | CNR1CNR2HTR2CNPC1RAB9A | |
| SCHEMBL3545070 | 0.82 | HTR2C (0.47) | CNR1CNR2HTR2CNPC1RAB9A | |
| SCHEMBL3541780 | 0.82 | HTR2C (0.57) | CNR1CNR2HTR2CNPC1RAB9A | |
| SCHEMBL3538914 | 0.82 | CNR1 (0.51) | CNR1CNR2HTR2CNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |