Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4974086 | 0.87 | HTR2C (0.60) | HTR2CKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL4973462 | 0.87 | HTR2C (0.60) | HTR2CKMT2AKDM4EMEN1NPC1 | |
| SCHEMBL4970307 | 0.84 | CNR1 (0.43) | HTR2CTRPC3TRPC6NPC1RAB9A | |
| SCHEMBL4971490 | 0.84 | HTR2C (0.42) | HTR2CPIN1 | |
| SCHEMBL4970437 | 0.83 | SCD5 (0.49) | HTR2CTRPC3TRPC6NPC1RAB9A | |
| SCHEMBL4971657 | 0.83 | HTR2C (0.44) | HTR2CTRPC3TRPC6GHSR | |
| SCHEMBL5665652 | 0.81 | HTR2C (0.48) | HTR2CTRPC3TRPC6KMT2AKDM4E | |
| SCHEMBL27751154 | 0.81 | HTR2C (0.45) | HTR2CTRPC3TRPC6KMT2AKDM4E | |
| SCHEMBL4972171 | 0.79 | SPR (0.44) | HTR2CNPC1RAB9A | |
| SCHEMBL27751153 | 0.79 | HTR2C (0.46) | HTR2CTRPC3TRPC6KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | claimed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | claimed |
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |