Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.54 |
| ▸ | THRA | P10827 | 8/20 | 0.44 |
| ▸ | THRB | P10828 | 8/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30274370 | 0.89 | EGLN1 (0.69) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL2537395 | 0.89 | EGLN1 (0.69) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL15547656 | 0.83 | EGLN1 (0.64) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL1115849 | 0.83 | EGLN1 (0.77) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL5076142 | 0.82 | EGLN1 (0.54) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL15549041 | 0.82 | EGLN1 (0.75) | EGLN1THRATHRBBBOX1SLC6A2 | |
| Water SCHEMBL15548472 | 0.82 | EGLN1 (0.75) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL15549510 | 0.82 | EGLN1 (0.75) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL15547171 | 0.80 | EGLN1 (0.60) | EGLN1THRATHRBEGLN2 | |
| SCHEMBL2541428 | 0.79 | THRA (0.72) | EGLN1THRATHRBBBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991269-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF STROKE | FIBROGEN, INC. (US) | 2008-11-19 | — | — | EP | disclosed |
| EP-1893186-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2007097929-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF STROKE | FIBROGEN, INC. (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2006133391-A2 | IMPROVED TREATMENT FOR ANEMIA USING A HIF-ALPHA STABILISING AGENT | FIBROGEN, INC. (US) | 2006-12-14 | — | — | WO | disclosed |