Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 13/20 | 0.51 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4968074 | 0.93 | SMO (0.52) | DGAT1SMOKMT2AAURKAAURKB | |
| SCHEMBL4971826 | 0.90 | SMO (0.50) | SMOKMT2ARAB9AEGFR | |
| SCHEMBL4972268 | 0.89 | SMO (0.52) | SMOMEN1KMT2AAURKAAURKB | |
| SCHEMBL398151 | 0.89 | SMO (0.53) | DGAT1SMOKMT2AAURKAAURKB | |
| SCHEMBL4971048 | 0.89 | RAB9A (0.50) | SMOKMT2AAURKAAURKBKCNQ3 | |
| SCHEMBL4970651 | 0.87 | SMO (0.51) | DGAT1SMOMEN1KMT2AKCNQ3 | |
| SCHEMBL4972061 | 0.87 | RAB9A (0.57) | SMOKMT2AKCNQ3KCNQ2RAB9A | |
| SCHEMBL402823 | 0.87 | SMO (0.59) | SMOMEN1KMT2ARAB9AEGFR | |
| SCHEMBL4971825 | 0.86 | RAB9A (0.54) | SMOKMT2ARAB9AEGFR | |
| SCHEMBL403537 | 0.86 | SMO (0.54) | SMOKCNQ3KCNQ2RAB9AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |