Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL403228 | 0.89 | NPC1 (0.58) | KMT2ANPC1RAB9AL3MBTL1MT-CO2 | |
| SCHEMBL4971344 | 0.88 | CCNT1 (0.44) | KMT2AL3MBTL1EGFRTP53ALDH1A1 | |
| SCHEMBL4968684 | 0.88 | ALDH1A1 (0.44) | MT-CO2EGFRTP53USP2ALDH1A1 | |
| SCHEMBL4972451 | 0.83 | SMO (0.58) | KMT2ANPC1RAB9AL3MBTL1EGFR | |
| SCHEMBL4970118 | 0.81 | MEN1 (0.52) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL400967 | 0.81 | NPC1 (0.46) | KMT2ANPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL462167 | 0.78 | NPC1 (0.54) | KMT2ANPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL4971603 | 0.78 | GAA (0.52) | KMT2ANPC1RAB9AL3MBTL1EGFR | |
| SCHEMBL1068026 | 0.78 | ALB (0.54) | TP53USP2ALDH1A1HPGDMAPK1 | |
| SCHEMBL403585 | 0.77 | SMO (0.55) | KMT2ANPC1RAB9AL3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |