Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4975393 | 0.85 | JAK2 (0.38) | JAK2JAK3KDM4ESMN1; SMN2ELOVL1 | |
| SCHEMBL4973170 | 0.82 | JAK2 (0.39) | JAK2JAK3KDM4EELOVL1TSHR | |
| SCHEMBL4974714 | 0.78 | JAK2 (0.47) | JAK2JAK3KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4974705 | 0.77 | JAK2 (0.49) | JAK2JAK3KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4970845 | 0.76 | JAK2 (0.64) | JAK2JAK3KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4975389 | 0.71 | JAK2 (0.61) | JAK2JAK3KDM4ESMN1; SMN2 | |
| SCHEMBL4972050 | 0.71 | JAK2 (0.46) | JAK2JAK3KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4975403 | 0.70 | JAK2 (0.49) | JAK2JAK3KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL4972038 | 0.70 | JAK2 (0.49) | JAK2JAK3KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4973163 | 0.69 | JAK2 (0.63) | JAK2JAK3KDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |