Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105264 | 0.89 | RXRA (0.66) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL30444032 | 0.89 | RXRA (0.66) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27676992 | 0.88 | RXRA (0.64) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL10455036 | 0.83 | RXRA (0.68) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL29427056 | 0.82 | ALDH1A1 (0.48) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL135394 | 0.82 | ALDH1A1 (0.48) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL14843614 | 0.80 | ANPEP (0.56) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| Ethane SCHEMBL17336854 | 0.80 | PARP1 (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9AMRGPRX4 | |
| Ammonia Solution, Strong SCHEMBL3178489 | 0.80 | ALDH1A1 (0.46) | RXRARXRBRXRGALDH1A1SMN1; SMN2 | |
| SCHEMBL29537403 | 0.80 | PARP1 (0.65) | ALDH1A1SMN1; SMN2MRGPRX4MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966159-A2 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007071963-A2 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |