Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971004 | 0.91 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL4974520 | 0.89 | PTGS2 (0.35) | PTGS2PTGS1ALOX5MAPK14MAPK9 | |
| SCHEMBL4973332 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1ALOX5 | |
| SCHEMBL4973843 | 0.78 | GPBAR1 (0.39) | PTGS2PTGS1MAPK14MAPK11 | |
| SCHEMBL4971139 | 0.78 | PTGS2 (0.46) | PTGS2PTGS1MAPK14 | |
| SCHEMBL4970748 | 0.77 | CACNA1F (0.35) | PTGS2PTGS1MAPK14 | |
| SCHEMBL3640427 | 0.76 | ESR1 (0.46) | PTGS2PTGS1MAPK14MAPK11 | |
| SCHEMBL4975266 | 0.74 | PTGS1 (0.40) | PTGS2PTGS1 | |
| SCHEMBL3647450 | 0.74 | PTGS2 (0.41) | PTGS2MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL4974345 | 0.73 | FFAR2 (0.35) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | claimed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |