Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970118 | 0.90 | MEN1 (0.52) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL4977786 | 0.90 | NPY1R (0.54) | MAPT | |
| SCHEMBL402272 | 0.87 | MAPT (0.67) | MEN1KMT2AMAPT | |
| SCHEMBL4970953 | 0.81 | DGAT1 (0.55) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL404320 | 0.80 | MAPT (0.54) | MEN1KMT2AMAPT | |
| SCHEMBL402353 | 0.79 | MAPT (0.52) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4970505 | 0.77 | POLB (0.57) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL4975360 | 0.77 | CYP2C9 (0.56) | — | |
| SCHEMBL1018498 | 0.76 | ALB (0.65) | MAPTKDM4EALDH1A1 | |
| SCHEMBL4969552 | 0.76 | MAPT (0.60) | MEN1KMT2AMAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |