Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
| ▸ | NPY2R | P49146 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | XPO1 | O14980 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971195 | 0.90 | MEN1 (0.53) | MAPT | |
| SCHEMBL402353 | 0.89 | MAPT (0.52) | NPY1RNPY2RTRPV1MAPT | |
| SCHEMBL4975360 | 0.87 | CYP2C9 (0.56) | — | |
| SCHEMBL4970118 | 0.84 | MEN1 (0.52) | MAPT | |
| SCHEMBL4968684 | 0.81 | ALDH1A1 (0.44) | NPY1RNPY2RTRPV1MAPT | |
| SCHEMBL17075551 | 0.80 | PTGS1 (0.48) | NPY1RNPY2RTRPV1MAPT | |
| SCHEMBL4970534 | 0.80 | SMO (0.50) | NPY1RNPY2RTRPV1 | |
| SCHEMBL402272 | 0.80 | MAPT (0.67) | MAPT | |
| SCHEMBL404320 | 0.77 | MAPT (0.54) | GRM5MAPT | |
| SCHEMBL4972665 | 0.77 | KCNQ3 (0.66) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | disclosed |