SCHEMBL4972146

SCHEMBL4972146

CC1CN(c2ccc(C(=O)Nc3ccc(Cl)c(Nc4ccc(F)cc4)c3)cn2)CCN1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMO Q99835 1/20 0.59
HDAC1 Q13547 6/20 0.56
IKBKB O14920 2/20 0.48
HDAC2 Q92769 3/20 0.47
HDAC3 O15379 2/20 0.47
MAPK7 Q13164 1/20 0.46
CTNNB1 P35222 4/20 0.45
TCF7L2 Q9NQB0 4/20 0.45
KCNQ3 O43525 1/20 0.43
KCNQ2 O43526 1/20 0.43
RAB9A P51151 1/20 0.43
HDAC10 Q969S8 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4971127 1.00 SMO (0.59) SMOHDAC1IKBKBHDAC2HDAC3
SCHEMBL402864 0.94 SMO (0.64) SMOHDAC1IKBKBHDAC2HDAC3
SCHEMBL399419 0.94 SMO (0.64) SMOHDAC1IKBKBHDAC2HDAC3
SCHEMBL402178 0.94 SMO (0.64) SMOHDAC1IKBKBHDAC2HDAC3
SCHEMBL4967912 0.92 HDAC1 (0.62) SMOHDAC1IKBKBMAPK7RAB9A
SCHEMBL4971491 0.92 HDAC1 (0.62) SMOHDAC1IKBKBMAPK7RAB9A
SCHEMBL4968097 0.88 HDAC2 (0.60) SMOHDAC1HDAC2HDAC3MAPK7
SCHEMBL404107 0.86 SMO (0.70) SMOHDAC1HDAC2MAPK7RAB9A
SCHEMBL403079 0.86 SMO (0.70) SMOHDAC1HDAC2MAPK7RAB9A
SCHEMBL403080 0.86 SMO (0.70) SMOHDAC1HDAC2MAPK7RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP claimed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO claimed
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP disclosed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO disclosed