SCHEMBL4968097

SCHEMBL4968097

O=C(Nc1ccc(Cl)c(Nc2ccc(F)cc2)c1)c1ccc(N2CCNCC2)nc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 8/20 0.60
HDAC3 O15379 6/20 0.60
MAPK7 Q13164 1/20 0.56
HDAC1 Q13547 4/20 0.54
HDAC10 Q969S8 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
SMO Q99835 1/20 0.51
KCNH2 Q12809 2/20 0.49
KCNQ3 O43525 2/20 0.49
KCNQ2 O43526 2/20 0.49
LMNA P02545 1/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
RAB9A P51151 1/20 0.47
CLK2 P49760 1/20 0.46
CLK3 P49761 1/20 0.46
DYRK1A Q13627 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL403550 0.93 HDAC2 (0.64) HDAC2HDAC3MAPK7HDAC1HDAC10
SCHEMBL4975497 0.91 KCNH2 (0.57) HDAC2HDAC3MAPK7HDAC1SMO
SCHEMBL4969870 0.88 SMO (0.50) HDAC2HDAC3MAPK7HDAC10HDAC6
SCHEMBL4972146 0.88 SMO (0.59) HDAC2HDAC3MAPK7HDAC1HDAC10
SCHEMBL4971127 0.88 SMO (0.59) HDAC2HDAC3MAPK7HDAC1HDAC10
SCHEMBL4973233 0.87 SMO (0.60) HDAC2HDAC3MAPK7HDAC1SMO
SCHEMBL4971048 0.87 RAB9A (0.50) HDAC2HDAC3HDAC10SMOKCNQ3
SCHEMBL4969481 0.86 CHRM1 (0.52) SMOKCNQ3KCNQ2SMN1; SMN2RAB9A
SCHEMBL4738294 0.86 HDAC2 (0.67) HDAC2HDAC3MAPK7HDAC1HDAC10
SCHEMBL4970125 0.85 SMO (0.48) HDAC2HDAC3MAPK7HDAC10HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP claimed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO claimed
EP-1957461-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING Genentech, Inc. (US) 2008-08-20 EP disclosed
WO-2007059157-A1 BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING GENENTECH, INC. (US) 2007-05-24 WO disclosed