Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12308618 | 0.76 | CA2 (0.38) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL22234198 | 0.74 | CA2 (0.39) | CHRM3SIGMAR1HPGDCA2CA12 | |
| SCHEMBL4972011 | 0.72 | CHRM5 (0.40) | CHRM5CHRM3SIGMAR1 | |
| SCHEMBL12308679 | 0.71 | CA2 (0.37) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL12308748 | 0.70 | CA2 (0.36) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL22236039 | 0.69 | CA2 (0.42) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL3938238 | 0.68 | CA2 (0.46) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL22233564 | 0.67 | GAA (0.38) | SIGMAR1HPGDCA2CA12CA1 | |
| SCHEMBL12308783 | 0.67 | GAA (0.38) | CHRM5CHRM3SIGMAR1HPGDCA2 | |
| SCHEMBL10683 | 0.66 | CA2 (0.48) | SIGMAR1HPGDCA2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968590-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007070865-A2 | PIPERAZINE COMPOUNDS AS AGONISTS OF TRPV4 CHANNEL RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |